Correction: Type III Effector Activation via Nucleotide Binding, Phosphorylation, and Host Target Interaction

نویسندگان

  • Darrell Desveaux
  • Alex U Singer
  • Ai-Jiuan Wu
  • Brian C McNulty
  • Laura Musslewhite
  • Zachary Nimchuk
  • John Sondek
  • Jeffrey L Dangl
چکیده

V128A þ þ NA NA þ NA D155, A162 contact Q208A 6 þ NA þ þ NA H167 contact R209A 6 6 NA þ þ NA F169 contact QRY/AAA 6 6 6 NA NA H167, F169, and C-term contact D213A þ þ NA NA NA NA W154 H-bond H217A 6 6 NA NA T166 H-bond Q265A þ þ NA NA þ NA I168 contact T182A þ þ NA NA þ NA F151 contact R266A þ NA þ Y165 contact (RIN4); b-Phosphate H-bond (ADP) L109A þ þ NA NA þ NA Y165 contact (RIN4); position AvrB R266 ADP pocket N62A 6 6 NA NA þ NA Purine ring Y65A NA NA þ þ Purine ring, ribose O2 H-bond R99A þ NA þ a-Phosphate H-bond F113A 6 6 NA NA þ NA Phosphate contact; position AvrB R99 and R266 Interlobe Y131A þ þ þ b-Phosphate (via H2O) D297A þ þ þ Purine ring, ribose O3 (via H2O)

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The roles of EPIYA sequence to perturb the cellular signaling pathways and cancer risk

Abstract It was shown that several pathogenic bacterial effector proteins contain the Glu-Pro-Ile-Tyr-Ala (EPIYA) or a similar sequence. These bacterial EPIYA effectors are delivered into host cell via type III or IV secretion system, where they undergo tyrosine phosphorylation at the EPIYA sequences, which triggers interaction with multiple host cell SH2 domain-containing proteins and thereby...

متن کامل

Type III Effector Activation via Nucleotide Binding, Phosphorylation, and Host Target Interaction

The Pseudomonas syringae type III effector protein avirulence protein B (AvrB) is delivered into plant cells, where it targets the Arabidopsis RIN4 protein (resistance to Pseudomonas maculicula protein 1 [RPM1]-interacting protein). RIN4 is a regulator of basal host defense responses. Targeting of RIN4 by AvrB is recognized by the host RPM1 nucleotide-binding leucine-rich repeat disease resista...

متن کامل

AvrRpm1 Missense Mutations Weakly Activate RPS2-Mediated Immune Response in Arabidopsis thaliana

Plants recognize microbes via specific pattern recognition receptors that are activated by microbe-associated molecular patterns (MAMPs), resulting in MAMP-triggered immunity (MTI). Successful pathogens bypass MTI in genetically diverse hosts via deployment of effectors (virulence factors) that inhibit MTI responses, leading to pathogen proliferation. Plant pathogenic bacteria like Pseudomonas ...

متن کامل

Specific threonine phosphorylation of a host target by two unrelated type III effectors activates a host innate immune receptor in plants.

The Arabidopsis NB-LRR immune receptor RPM1 recognizes the Pseudomonas syringae type III effectors AvrB or AvrRpm1 to mount an immune response. Although neither effector is itself a kinase, AvrRpm1 and AvrB are known to target Arabidopsis RIN4, a negative regulator of basal plant defense, for phosphorylation. We show that RIN4 phosphorylation activates RPM1. RIN4(142-176) is necessary and, with...

متن کامل

Identification of a molecular target for the Yersinia protein kinase A.

Pathogenic bacteria of the genus Yersinia employ a type III secretion system to inject bacterial effector proteins directly into the host cytosol. One of these effectors, the Yersinia serine/threonine protein kinase YpkA, is an essential virulence determinant involved in host actin cytoskeletal rearrangements and in inhibition of phagocytosis. Here we report that YpkA inhibits multiple Galphaq ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • PLoS Pathogens

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2007